Saffron: An impressive portfolio of health benefits from this age-old spice – Part 1

Saffron (Crocus sativus) is the world’s most expensive spice. That’s because it is still hand-harvested from the beautiful lilac-purple flowers of a small low-growing crocus. Each flower yields only three small threadlike stigmas that are bright orange-red and form the spice as we know it. This intense orange-red colour comes from an extraordinarily high content of carotenoid molecules, mainly the crocins. When we consume saffron, the crocins release the carotenoid crocetin into our bloodstream. The saffron stigma is a superconcentrated source of highly bioavailable carotenoids, with health-promoting properties similar to, but unique from, other key carotenoids such as astaxanthin and lutein.

I first wrote about the new clinical research on saffron in this column five years ago. In that article I outlined the results of five clinical trials where saffron was shown to be more effective than a placebo at alleviating depression1,2 and just as active as conventional drugs, including fluoxetine (Prozac).3,4,5

Saffron successfully relieved sexual dysfunction

Since that article, many more published trials have demonstrated that saffron has a wide range of health benefits. In the case of depression, there have been two new trials that looked at the effect of using saffron in depressed patients suffering from sexual dysfunction as a side effect of the drug fluoxetine. The first trial tested the influence of saffron on fluoxetine-induced sexual dysfunction in men.6 This was a four-week randomised, double blind, placebo-controlled study. Thirty-six married male patients with major depressive disorder whose depressive symptoms had been stabilised on fluoxetine and had subjective complaints of sexual impairment entered the study. The patients were randomly assigned to saffron extract (15mg twice per day) or placebo for four weeks. The International Index of Erectile Function scale was used to assess sexual function at baseline and weeks two and four.

Improved erectile function and intercourse satisfaction

Thirty patients finished the study. Baseline characteristics as well as baseline and final depressive symptoms scores were similar between the two groups. By week four, saffron resulted in significant improvement in erectile function, intercourse satisfaction, and total scores than the placebo group. Nine patients (60%) in the saffron group and one patient (7%) in the placebo group achieved normal erectile function (score >25 on erectile function domain) by the end of the study. The frequency of side effects was similar between the two groups.

In the second trial, the impact of saffron on fluoxetine induced sexual dysfunction was assessed in women.7 Using a similar trial design to the above, 38 women with major depression who were stabilised on fluoxetine 40mg/day for a minimum of six weeks and had experienced subjective feelings of sexual dysfunction entered the study. The patients were randomly assigned to saffron extract (30mg/daily) or placebo for four weeks. Measurement was performed at baseline, week two and week four using the Female Sexual Function Index (FSFI). Side effects were systematically recorded.

Improved sexual function and arousal in women

Thirty-four women had at least one post-baseline measurement and completed the study. At the end of the fourth week, patients in the saffron group experienced significantly greater improvement in total FSFI, and for the arousal, lubrication and pain domains of the FSFI. Frequency of side effects was similar between the two groups.

These new trials highlight an important advantage of saffron in depression, it appears to be quite safe to add to conventional antidepressant drugs. For further information on this topic please see the sidebar on page 4 – I have separated this discussion from the main article as it is quite complex and only suitable for the technical reader.

The take away from these studies is that saffron is highly unlikely to adversely interact with modern antidepressant drugs, especially selective serotonin re-uptake inhibitors (SSRIs). Specifically, there’s absolutely no suggestion from current research that the herb substantially influences serotonin metabolism.

To your better health,

Kerry Bone
Nutrition & Healing

Volume 7, Issue 6 –  June 2013


Full references and citations for this article are available in the downloadable PDF version of the monthly Nutrition and Healing issue in which this article appears.

Leave a comment

Be part of the conversation by becoming a Premium Member. Click here to learn more about membership.


Leave a Reply

Your email address will not be published. Required fields are marked *